Razak Omotoyossi will make his debut for Zamalek when they take on Military Production in Suez on Friday.
Benin striker Omotoyossi was named in Zamaleks 18-man list for the first time since joining the team
He replaces striker Hamdi who is struggling with a back problem, while midfielder Al-Merghani was left out due to a groin injury.
Amr Zaki is Zamaleks only reliable striker, with the likes of Ahmed Gaafar and new signing Hussein Hamdy failing to impress as his partners up front.
Ahmed Hossam Mido, who scored on his first appearance since joining Zamalek last January when the team thrashed Ghazl El-Mahalla 6-1 in their opening game of the season, is still suffering from fitness and weight problems.
He missed training for two days without permission, prompting Zamalek to fine him.