The Ghanian FA had urged FIFA to find “a safe and secure venue” on neutral territory for the 19 November game following recent violence in the Egyptian capital.
However, FIFA on Wednesday confirmed Cairo as the venue after a visit by inspectors and a demand that Egypt provide security guarantees, it said in a letter to both countries released by the Ghana FA.
The winners of the playoff will qualify for next year’s World Cup in Brazil.
Egypt are highly unlikely to end their 24-year World Cup absence after they were hammered 6-1 by Ghana in Kumasi in the first leg. The second leg will be played at the army-owned Air Defence Stadium in Cairo.
