A trademark header by central defender Mahmoud Fathallah gave the Cairo giants a first-half lead.
A superb Shikabala free-kick midway through the second period ensured ENPPI would have a mountain to climb to get something from the game
The hosts, who were looking to ease their African woes after suffering two successive defeats in the Confederation Cup, pulled one back via a powerful Ahmed Al-Muhammadi drive with three minutes remaining.
Substitute Ahmed Al-Merghani killed off ENPPI’s hopes when he notched home deep into stoppage time to cap an impressive attacking display from Zamalek.
Goals:
