Zamalek claimed a narrow 1-0 victory over Wadi Degla in their previous league game but they were far from impressive, casting doubts over their title credentials.
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Former Egypt coach Hassan Shehata has yet to settle on his ideal formation as Zamalek, who lie fourth in the table, three points behind Ahly, take on Gouna in Wednesday�s late encounter.
They were boosted after Amr Zaki resolved his financial dispute with the club but the combative striker will not be available for the Gouna tie due to lack of fitness.
Abdul-Shafi has been forced off Zamalek�s 1-0 league victory against Wadi Degla at half-time with a groin complaint.
Center-half Salah Soliman also failed to make the squad for the second game on the trot due to a knock in the knee.
Meanwhile, forwards Mido and Ahmed Hassan have been declared fit for the Gouna game despite being initially doubtful for the home fixture.