Ismaily beat El Gaish 2-1 away from home, with striker Ahmed Aly scoring the winning goal.
El Gaish took the lead through Mohamed Zaki on the hour mark but substitute Abdullah Al-Shahhat leveled for the Dervishes five minutes later.
Egypt international striker Ahmed Ali, who faced severe criticism after his poor show against Al Ahly last week, hit the winner with four minutes remaining on the clock.
Ismaily moved to fifth place with 17 points.
Watch the goals here: