Ivory Coast will be without midfielder Cheick Tiote and forward Gervinho, who are both suspended.
Max Gradel could start after coming off the bench to grab a late equaliser against Mali and Salomon Kalou is also hoping for a recall to the starting XI.
Cameroon are set to once again be without midfielder Eyong Enoh, who injured his left thigh in the opening match against Mali.
Group D could not be tighter with all previous games having ended 1-1.
It means that if the final two games in the group end in identical draws, it will require the drawing of lots to determine who goes through to the quarter-finals, and in which order.
That would not be unprecedented, with the drawing of lots required at the 1988 Cup of Nations to send Algeria through to the knockout stage at the expense of the Ivory Coast, who had drawn all three of their matches.
The 2015 version of the Elephants will hope to win and thereby avoid a similar fate.
Coach Herve Renard said: “Cameroon have experienced players in every department. For us, except for Kolo Toure, we have no other experienced defender.
“It is a match that will be decided by little details. Concentration, an ability to take our chances and defensive rigour will all be important. Whichever team shows a little less of these things will go home.”
Recent history suggests Cameroon are best placed to win this encounter, though. The Indomitable Lions won their qualifying group ahead of the Ivorians, trouncing the Elephants 4-1 in Yaounde in September before drawing 0-0 in the return match in Abidjan in November.
“We go for a win,” Cameroon coach Volker Finke said. “But I know we have to work very hard against the ball. There are excellent individual players in the team of Ivory Coast.”
Live Cameroon vs Ivory Coast | Africa Cup of Nations